WebStudy of these latter substances, the uncoupling agents, reveals further subgrouping: 1) those agents which stimulate oxygen consumption and are insensitive to magnesium ion changes ( e.g., dinitrophenol) and 2) agents which do not stimulate oxygen consumption while depressing phosphorylation and whose action is reversed by magnesium ions ( e.g., … Web19 Jul 2024 · Medical Definition of uncoupler : an agent that dissociates two integrated series of chemical reactions especially : one that prevents the formation of ATP in …
5.5: Uncoupling Electron Transport from ATP Synthesis
WebIn the early 1930s, the chemical uncoupling agent 2,4-dinitrophenol (DNP) was promoted for the very first time as a powerful and effective weight loss pill but quickly withdrawn from … An uncoupler or uncoupling agent is a molecule that disrupts oxidative phosphorylation in prokaryotes and mitochondria or photophosphorylation in chloroplasts and cyanobacteria by dissociating the reactions of ATP synthesis from the electron transport chain. The result is that the cell or … See more Classical uncouplers have five properties: 1. the complete release of respiratory control 2. the substitution of all coupled processes (ATP synthesis, transhydrogenation, reverse electron flow, active transport of … See more • Uncoupling protein • Mitochondrial toxicity See more • Uncoupling+Agents at the U.S. National Library of Medicine Medical Subject Headings (MeSH) See more The following compounds are known to be classical uncouplers: • 2,4-dinitrophenol (DNP) • 2,5-dinitrophenol • 1799 (α,α′-bis(hexafluoracetonyl)acetone) See more The following compounds are known to be pseudo-uncouplers: • Azide • Biguanides • Bupivacaine See more sowesign solutions
Web25 Apr 2024 · Toth P, Szarka N, Farkas E, et al. Traumatic brain injury-induced autoregulatory dysfunction and spreading depression-related neurovascular uncoupling: pathomechanisms, perspectives, and therapeutic implications. Am J Physiol … Web23 Aug 2024 · Metabolism and Clearance Elimination Bolus and Infusion Kinetics Drug Monitoring Epidural and Intrathecal TIVA and TCI Pharmacodynamics Receptor Theory Receptor Types Dose-Response Curves Mechanisms of Action Variability in Drug Response Adverse Effects Drug Interactions Alterations to Response Pharmacogenetics Drugs in … Web解偶联剂 (uncoupling agent ):一种不阻止呼吸链中的电子传递 , 也 不作用于 ATP 合酶复合体 ,但能够消除其跨膜的质子浓度梯度 ,从而 使 ATP 不能合成 。这种只解除电子传递与 ADP 磷酸化之间紧密偶联关系 的化合物称为解偶联剂 。 例如 2,4-二硝基苯酚 。 team lead role in accenture