Stub1 chip
WebMar 26, 2024 · CHIP/STUB1 Antibody (C-10) is a mouse monoclonal IgG 1 κ, cited in 16 publications, provided at 200 µg/ml raised against amino acids 73-303 mapping at the C-terminus of CHIP of human origin Anti-CHIP/STUB1 Antibody (C-10) is recommended for detection of CHIP of mouse, rat and human origin by WB, IP, IF and ELISA Webnote = "Funding Information: We thank Dr. Ana Maria Cuervo for providing the shRNA against Lamp2a and Atg7 lentiviral vectors, and the NIH-3T3 cells, Dr. Thilo Hagen for the wild-type and proline mutant HIF1A constructs, Dr. Cam Patterson for the wild-type and mutant STUB1 constructs, and Dr. Roland H. Wenger for the Hif1a+/+ and hif1a−/− MEFs.
Stub1 chip
Did you know?
WebThis product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility. - Improved sensitivity … WebRecently, the carboxyl terminus of Hsp70-interacting protein (CHIP), also known as STIP1 homology and U-box containing protein 1 (STUB1), has been identified as a critical regulator of necroptosis . CHIP is a 34.5-kDa cytoplasmic protein comprising the N-terminal tetratricopeptide (TPR) domain, C-terminal U-box domain, and a central coiled-coil ...
WebOct 25, 2005 · Antibodies against STUB1 are found in patients with chronic lymphocytic leukemia (CLL) and in colorectal cancer patients. Catalytic activity S-ubiquitinyl- [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N6-ubiquitinyl- [acceptor protein]-L-lysine. 3 publications WebSTIP1 Homology and U-box Containing Protein 1 (STUB1), also known as Carboxyl Terminus of Hsp70-interacting Protein (CHIP), is a cytoplasmic protein that functions as a U-box Ubiquitin ligase (E3) (1). It is highly expressed in striated muscle and brain and has been observed at lower levels in other organs including the pancreas, lung, liver ...
WebDescription: Homo sapiens STIP1 homology and U-box containing protein 1 (STUB1), transcript variant 2, mRNA. (from RefSeq NM_001293197) RefSeq Summary (NM_001293197): This gene encodes a protein containing tetratricopeptide repeat and a U-box that functions as a ubiquitin ligase/cochaperone. The encoded protein binds to and … WebNov 16, 2024 · STUB1 disassociates AR/AR-V7 from HSP70, leading to AR/AR-V7 ubiquitination and degradation. ... The co-chaperone CHIP regulates protein triage decisions mediated by heat-shock proteins. Nat. Cell ...
WebJul 27, 2024 · The STUB1 gene (STIP1 Homology And U-Box Containing Protein 1) encodes the CHIP protein containing tetratricopeptide repeats and a U-box that functions as a ubiquitin ligase/cochaperone, involved ...
WebOct 15, 2024 · Data indicated that STUB1 deficiency leads both to the intracellular accumulation of protein aggregates and to an increase in the secretion of small … dickies lp703 relaxed fit lightweight ripstoWebSTUB1/CHIP is required for HIF1A degradation by chaperone-mediated autophagy. The transcription factor HIF1 is mostly regulated by the oxygen-dependent proteasomal … citizen space northern ireland assemblyWebSTUB1, also named as CHIP, SDCCAG7, UBOX1 and NY-CO-7, is a E3 ubiquitin-protein ligase which targets misfolded chaperone substrates towards proteasomal degradation. STUB1/CHIP modulates the activity of several chaperone complexes, including Hsp70, Hsc70 and Hsp90. It mediates transfer of non-canonical short ubiquitin chains to HSPA8 … citizen space priority catchmentsWebSee all STUB1/CHIP primary antibodies Description Rabbit monoclonal [EPR4448] to STUB1/CHIP Host species Rabbit Tested applications Suitable for: WB, ICC/IF more details Unsuitable for: Flow Cyt or IHC-P Species … citizen space scotlandWebApr 8, 2024 · More interestingly, the E3 ubiquitin ligase STIP1 homology and U-box containing protein 1 (STUB1, also known as CHIP and encoded by STUB1) emerged as … citizen space rathlinWeb2 days ago · The E3 ligases c-Cbl and CHIP are ubiquitination regulators of BCR/ABL. 23 They induce ubiquitin-dependent degradation of mature and immature BCR/ABL, respectively, and efficiently suppress BCR/ABL-dependent leukemic growth. 23 Arsenic sulfide (As 4 S 4) has been reported to upregulate c-Cbl, to enhance the ubiquitination and … dickies lt work shirtWebSTUB1 encodes for the protein C-terminus of Hsc70 Interacting Protein (CHIP), an E3 ubiquitin ligase. CHIP is known to regulate proteostasis by recruiting chaperones via a N-terminal… Show more dickies lp710 pleated pant