Cisplatin sensitivity

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August undefined, 2024

WebFactors contributing to the observed cisplatin sensitivity include defective DNA damage repair and a hypersensitive apoptotic response to DNA damage. Nonetheless, around 10 … WebMay 1, 2003 · In such an instance, cancer cells may escape the apoptotic consequence of cisplatin exposure but still sustain major genotoxic insults. Considering that apoptosis may be impaired, using...

d-Borneol enhances cisplatin sensitivity via p21/p27 …

WebJul 22, 2024 · Figure 1 Olaparib and cisplatin (CDDP) in vitro sensitivities are not influenced by the BRCA1 status of TNBC cells. (A) MTT assays of MDA-MB-468, SUM1315, MDA-MB-231 and HCC1937 cells. Data are mean ± S.D. of three independent experiments. (B) Isobologram analysis of the combination of olaparib and CDDP in constant 1:1 ratio. WebSep 30, 2014 · The lack of normal ERCC2 function may contribute to cisplatin sensitivity in urothelial cancer, and somatic ERCC2 mutation status may inform cisplatin-containing regimen usage in muscle-invasive urothelial carcinoma. the pink chicken anna maria

Enhanced Cisplatin Cytotoxicity by Disturbing the Nucleotide …

WebDetermining the factors that influence cellular sensitivity to cisplatin is thus important for understanding the anticancer activity of cisplatin and for developing a more effective platinum-based chemotherapy. The cytotoxicity of cisplatin arises from its ability to react with DNA and form covalent DNA adducts ( 4 ). Web2 days ago · Blockade of neddylation increases cisplatin sensitivity of testicular germ cell tumors. In turn, inhibition of the neddylation cascade leads to an accumulation of suppressor proteins and ... WebAug 24, 2024 · Cisplatin (CDDP) remains one of the most widely used first-line drugs in the therapy of NSCLC, based on the clinical data that the poor outcomes of untreated … the pink cherry salmon arm

Unravelling mechanisms of cisplatin sensitivity and resistance …

Reduced RBPMS Levels Promote Cell Proliferation and …

WebMar 25, 2024 · RRS1 silencing increased the sensitivity of MCF-7/DDP cells to cisplatin and inhibited cancer cell proliferation by blocking cell cycle distribution and enhancing apoptosis. AEG-1 (astrocyte elevated gene-1) promotes drug resistance by interfering with the ubiquitination and proteasomal degradation of MDR1 (multidrug resistance gene 1), … the pink chicken boutiqueWebCarboplatin sIgE is very specific but less sensitive. In contrast, oxaliplatin sIgE had higher sensitivity but lower specificity. Analysis of our data suggests that oxaliplatin exposure … the pink church

"WebMar 15, 2003 · Cisplatin-resistance cell lines CP70, C30, and C200 were produced by intermittent, incremental exposure of the sensitive parental A2780 cell line to various concentrations of cisplatin. OVCAR-4 and OVCAR-10 cell lines were developed from patients who were clinically refractory to platinum-based chemotherapy (16, 17). " - Cisplatin sensitivity

Cisplatin sensitivity

Targeted therapy for cisplatin‐resistant lung cancer via …

WebDec 9, 2024 · By analysing RNA-seq data in OSCC cells treated with vitamin D and cisplatin, we found that lipocalin 2 (LCN2) was an important modulator of cisplatin … WebA recent study indicated that NKX2-1 may modulate cellular sensitivity to cisplatin by modulating the β-catenin pathway through phosphorylation of AKT . We here …

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WebMay 1, 2005 · Analysis of A2780 cell sensitivity to cisplatin revealed a toxicity curve similar to that published previously ( 8) and a LD 50 of 3.0 μmol/L was calculated (data … WebNov 15, 1987 · Two sublines were derived from a human bladder carcinoma continuous cell line (RT112-P), one by exposure to fractionated X-irradiation (RT112-DXR8) and the other by continuous exposure to cisplatin (RT112-CP). RT112-DXR8 cells were 1.6- to 2-fold more sensitive to cisplatin and 2 analogues, carbopla …

WebDec 7, 2024 · TTK silencing increased cisplatin sensitivity by activating the mammalian target of rapamycin (mTOR) complex to further suppress cisplatin-induced … WebJan 4, 2024 · Although many mechanisms of cisplatin resistance have been proposed, the key mechanisms of such resistance remain elusive. The RNA binding protein with multiple splicing (RBPMS) binds to nascent RNA transcripts and regulates splicing, transport, localization, and stability.

WebMar 8, 2024 · XPV fibroblasts are sensitive to UV light and cisplatin but are corrected by transfection of POLHcDNA [1,13]. In this context, it is reasonable to postulate that human germline POLHvariants can alter the TLS activity and thus modify the susceptibility to toxic effects of UV and cisplatin in genetically affected individuals. WebWorldwide, the number of cancer-related deaths continues to increase due to the ability of cancer cells to become chemotherapy-resistant and metastasize. For women with …

WebMay 1, 2003 · In such an instance, cancer cells may escape the apoptotic consequence of cisplatin exposure but still sustain major genotoxic insults. Considering that apoptosis …

WebJul 26, 2024 · Background: Cisplatin (CDDP) is commonly used to treat non-small cell lung cancer (NSCLC), but the appearance of drug resistance greatly hinders its … the pink chicken anna maria islandWebOct 13, 2024 · Extensive research has been conducted to understand and overcome platinum resistance, and mechanisms of resistance can be categorized into several broad biological processes, including (1)... the pink chihuahuaWebDec 2, 2024 · However, the underlying role and mechanism of circZNF609 in bladder cancer (BCa) development and cisplatin chemosensitivity were unknown. Quantitative real-time PCR (qRT-PCR) was applied to determine the expression of circZNF609, microRNA 1200 (miR-1200) and CDC25B in BCa cells and tissues. thepinkchurch.orgWebNov 15, 1987 · Two sublines were derived from a human bladder carcinoma continuous cell line (RT112-P), one by exposure to fractionated X-irradiation (RT112-DXR8) and the … the pink church.comWebMay 14, 2024 · Cisplatin is a highly effective chemotherapy regimen for individuals with BCa. However, cisplatin-based chemotherapy would be effective in less than 50% of BCa patients (Sagalowsky 2013 ). Cell-cycle regulation is one of the major determinants of cisplatin chemosensitivity (Yang et al. 2024; Borst et al. 2014 ). the pink chair senoia gaWebWorldwide, the number of cancer-related deaths continues to increase due to the ability of cancer cells to become chemotherapy-resistant and metastasize. For women with ovarian cancer, a staggering 70% will become resistant to the front-line therapy, cisplatin. Although many mechanisms of cisplatin resistance have been proposed, the key mechanisms of … side effect of botox injectionWeb2 days ago · Cisplatin is used successfully in the chemotherapy of testicular cancer. However, patients who develop resistance to the cytostatic drug urgently need … the pink church boutique