Cholesterylamine
WebA hydrolytically stable sugar phosphonate coupled to a steroid a long and semi-rigid spacer (synthesized a 12-step sequence) binds both to the mannose-6-phosphonate … WebApr 1, 2024 · The chemical syntheses of 21MN-27MN were achieved by following conditions outlined in Scheme 1.Briefly, reaction of cholesterylamine 1 and N-2-bromo-ethyl-phthalimide followed by Boc protection gave intermediate 2, which was refluxed with NH2NH2 in ethanol followed by reaction with 2-nitrobenzenesulfonyl (Nosyl) chloride to …
Cholesterylamine
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WebAug 13, 2015 · We synthesized mimics of cholesterol, fluorescent N-alkyl-3β-cholesterylamine-glutamic acids, that are rapidly incorporated into cellular plasma membranes compared with analogous cholesteryl amides, ethers, esters, carbamates, and a sitosterol analogue. This process was inhibited by ezetimibe, indicating a receptor … WebNov 13, 2015 · Strikingly, we found that cholesterylamine (CholA) anchored glycopolymers are internalized into vesicles that serve as depots for delivery back to the cell surface, allowing for the display of cell-surface glycopolymers for at least ten days, even while the cells are dividing. As with native mucins, the cell-surface display of CholA-anchored ...
WebSearch Constraints Start Over You searched for: Author Last Name Sun Remove constraint Author Last Name: Sun Access Level open_access Remove constraint Access Level: open_access WebAug 6, 2008 · The ability of appropriately designed N-alkyl-3beta-cholesterylamines to deliver cargo into and release disulfide-linked cargo from relatively nonhydrolytic …
Webreceptor comprising 3β-cholesterylamine linked to the antibiotic vancomycin and bearing two glutamic acid residues in the linker region significantly enhanced the uptake of a fluorophore linked to a L-Lys-D-Phe-D-Ala tripeptide. The high efficiency of this delivery system may have potential application in the delivery of
WebJun 5, 2002 · The synthetic ligand described herein represents a designed cell surface receptor capable of targeting streptavidin conjugates into diverse mammalian cells by hijacking the molecular machinery used to organize cellular membranes. This technology has potential applications in DNA delivery, tumor therapy, and stimulation of immune …
WebJan 1, 2007 · To circumvent natural receptors required for endocytic drug delivery, we constructed a small artificial cell surface receptor comprising the membrane anchor N-alkyl-3β-cholesterylamine linked to a D-Phe-D-Ala motif that binds the glycopeptide antibiotic vancomycin. By mimicking membrane association and trafficking properties of cholesterol ... css exam schedule 2021WebPG-cholesterylamine is a derivative of N-alkyl-3β-cholesterylamine labeled with a fluorescein derivative, Pennsylvania Green (PG). Compared with the traditional radioisotope-based assay, this fluorescent probe gave similar results in the presence of known modulators of cholesterol efflux, such as cyclic AMP, and different cholesterol acceptors css exams stands forWebAs a strategy to prevent the exposure of cargo to these highly hydrolytic membrane-sealed compartments, we synthesized derivatives of the membrane anchor N-alkyl-3β … ear institute pretoria phone numberWebMay 15, 2024 · National Center for Biotechnology Information ear internal bleedingColestyramine (INN) or cholestyramine (USAN) (trade names Questran, Questran Light, Cholybar, Olestyr) is a bile acid sequestrant, which binds bile in the gastrointestinal tract to prevent its reabsorption. It is a strong ion exchange resin, which means it can exchange its chloride anions with anionic bile acids in the gastrointestinal tract and bind them strongly in the resin matrix. The functi… ear inspoWebDec 1, 2013 · A novel and stereoselective synthetic method for the preparation of 3α-cholesterylamine was developed. This method had many features, such as easily accessible cholesterol starting material, high... ear internationalWebThe C17-THP derivative of 7α-(11-azidoundecanyl)-estradiol (4) was synthesized and coupled to an aminomethyl resin via a photolabile o-nitrobenzyl linker. Reduction of the azide by the Staudinger reaction to its corresponding amine followed by acylation using four activated NFmoc protected amino acids gave a first level of diversity. Subsequent … css exams information